Related Papers
Allergy, Asthma, and Clinical Immunology
Airways Disease: Phenotyping Heterogeneity Using Measures of Airway Inflammation
2007 •
Salman Siddiqui
Pediatric Pulmonology
Pattern of airway inflammation and its determinants in children with acute severe asthma
1999 •
Kellie Fakes
International Journal of Chronic Obstructive Pulmonary Disease
Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD
Annals of Allergy Asthma & Immunology
Profiles of proinflammatory cytokines in sputum from different groups of severe asthmatic patients
2006 •
Federico L. Dente
COPD
Long-term effects of budesonide on inflammatory status in COPD
2008 •
T.A. Out
A beneficial effect of long-term corticosteroid treatment in patients with COPD may be linked to suppressing inflammation, in particular neutrophilic inflammation. Effects on neutrophilic and eosinophilic inflammation and on lung function of long-term inhaled budesonide treatment (800 microg daily, 6 months, double-blind, randomised, cross-over versus placebo) were studied and compared to the effects of 3 weeks oral prednisolone (30 mg daily) in 19 patients with COPD (mean age 63 y, FEV(1) 65% of predicted). Neither treatment influenced neutrophilic inflammation. Inhaled budesonide compared to placebo significantly reduced sputum % eosinophils at 3 months (-42%, p = 0.036), but not significantly at 6 months (-31%, p = 0.78). Eosinophil count per g sputum was decreased with 30% at 3 months (p = 0.09) and with 9% at 6 months (p = 0.78). FEV(1) was slightly higher after 6 months budesonide (+2.5% predicted, p = 0.09). Prednisolone significantly reduced sputum % eosinophils (-87%, p = 0...
Therapeutics and clinical risk management
Sputum analysis in diagnosis and management of obstructive airway diseases
2005 •
Paige Lacy
Induced sputum analysis has recently emerged as a potential new clinical tool in the diagnosis and management of obstructive airway diseases such as asthma, chronic obstructive pulmonary disease, and other disorders including bronchiectasis. Its safety has been demonstrated in numerous studies, and its efficacy is superior to previous techniques for determining airway inflammation. It is a noninvasive and highly reproducible approach in generating a measurable index of inflammatory cells in the airways of the lungs. Recent studies have shown that exacerbations, particularly in patients with moderate to severe asthma, can be reduced by routine analysis of induced sputum samples. We now have the ability to clinically apply sputum measurements to manage asthmatics. Inflammatory markers and cell types in induced sputum can also be investigated using newer technologies with more sensitive qualitative and quantitative features than basic cellular analysis. This review outlines the procedu...
Jornal Brasileiro de Pneumologia
Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis
2014 •
Emílio Pizzichini
OBJECTIVE: To evaluate the effect size of oral corticosteroid treatment on eosinophilic bronchitis in asthma, through systematic review and meta-analysis. METHODS: We systematically reviewed articles in the Medline, Cochrane Controlled Trials Register, EMBASE, and LILACS databases. We selected studies meeting the following criteria: comparing at least two groups or time points (prednisone vs. control, prednisone vs. another drug, or pre- vs. post-treatment with prednisone); and evaluating parameters before and after prednisone use, including values for sputum eosinophils, sputum eosinophil cationic protein (ECP), and sputum IL-5-with or without values for post-bronchodilator FEV1-with corresponding 95% CIs or with sufficient data for calculation. The independent variables were the use, dose, and duration of prednisone treatment. The outcomes evaluated were sputum eosinophils, IL-5, and ECP, as well as post-bronchodilator FEV1. RESULTS: The pooled analysis of the pre- vs. post-treatm...
Expert Review of Clinical Pharmacology
The asthma–chronic obstructive pulmonary disease overlap syndrome: pharmacotherapeutic considerations
2013 •
Timothy Albertson
Canadian respiratory journal : journal of the Canadian Thoracic Society
Heterogeneity of bronchitis in airway diseases in tertiary care clinical practice
NESREEN HASSAN
Sputum cell counts have identified inflammatory subtypes of bronchitis in relatively small numbers of subjects with asthma, chronic obstructive pulmonary disease (COPD) and chronic cough in research studies. The prevalence of different subtypes of bronchitis in routine clinical practice, however, has not been reported. To examine the heterogeneity of bronchitis and its relationship to the severity of airflow obstruction. A retrospective cross-sectional survey based on a computerized database of spontaneous or induced sputum cell counts examined in a large university tertiary respiratory outpatient clinic. The database contained 4232 consecutive sputum records from 2443 patients with chronic cough (39%), asthma (37%), asthma with COPD (9%), COPD (13%) and bronchiectasis (3%). Total and differential cell counts were obtained from 86% of successful sputum samples. Induced sputum provided more viable samples than spontaneous expectorate. Approximately one-third of patients with asthma a...
European Respiratory Journal
Prednisone-dependent asthma: inflammatory indices in induced sputum
1999 •
Emilio Pizzichini
